Sage at AACR
Enabling radically collaborative cancer research.
Helping cancer research teams accelerate their work and extend their impact.
Enabling discovery and empowering communities through the support of sponsored cancer research programs and global partnerships
Cancer research portfolio
Where cancer researchers collaborate across systems — from real-world data to cell atlases to open discovery.
Multi-Consortia Coordinating Center (MC² Center)
The NCI-funded Multi-Consortia Coordinating (MC2) Center connects a transdisciplinary research community across six NCI-funded consortia programs.
Led by Sage Bionetworks, the MC2 Center empowers community-building and collaboration across career stages and roles, through working groups, steering committees, annual meetings, trainings, and other outreach events. Research outputs, data, and tools are shared through the Cancer Complexity Knowledge Portal.
- Community Members800+
- Event Attendees600+ Annually
- Supported Grants160+
- Curated Datasets1,000+
AACR Project GENIE® is an American Association for Cancer Research initiative that links tumor genomic profiles to real world clinical outcomes across more than 20 cancer centers, covering over 200,000 patients.
Sage Bionetworks has been part of the Coordinating Center since the project launched, building the pipelines, harmonization tools, and governance scaffolding that make cross-institutional sharing actually work.
- Patients227,000+
- Samples270,000+
HTAN is a National Cancer Institute (NCI)-funded initiative to construct 3-dimensional atlases of the dynamic cellular, morphological, and molecular features of human cancers as they evolve from precancerous lesions to advanced disease.
The HTAN Data Coordinating Center, led in partnership by Sage Bionetworks, ISB, MSKCC, and DFCI, standardizes, integrates, and distributes multimodal tumor data to ensure long-term reuse, interoperability, and impact.
- Atlases24
- Cases2000+
- Cancer Types60+
- Organs20
- Multimodal data300+ TB
- Biospecimens10,000+
Cancer Challenges are open, community-driven competitions that bring together global researchers to benchmark methods, accelerate discovery, and advance cancer research through transparent evaluation.
Hosted on Synapse and supported by Sage Bionetworks, these Challenges enable reproducible science by providing shared datasets, objective evaluation metrics, and open leaderboards to solve problems across critical cancer domains. Browse all active and upcoming cancer-related Challenges, and the full catalog of open biomedical Challenges across disease areas, on the Sage Challenge Portal.
Explore Cancer ChallengesHow We Work
We support infrastructure, engineering, and governance across leading cancer research programs. Learn how we build platforms and partnerships that accelerate open, reproducible science.
Community Organization
We support a collaborative cancer research community through shared data, resources and tools, as well as opportunities to learn and work together. These community interactions drive new collaborations, transdisciplinary science, and faster and more novel scientific discoveries.
Data Infrastructure
We design and maintain research platforms, data pipelines, and analysis tools that enable scientists to explore complex datasets, reproduce results, and collaborate efficiently at scale.
Data Governance
We establish governance frameworks that balance openness with responsibility—supporting consent, privacy, access controls, and compliance so data can be shared ethically and sustainably.